Anti-CD40 Polyclonal Antibody

品牌：Solarbio | 货号：K001603P

K001603P-50ul	Solarbio	50ul	960.00元
K001603P-100ul	Solarbio	100ul	1600.00元

英文名称	Rabbit CD40 Polyclonal Antibody
应用2	WB IF
克隆类型2	Polyclonal Antibody
别名	AC133;CD133;CORD12;MCDR2;MSTP061;PROML1;RP41;STGD4
应用	WB,IF
稀释比例	WB1:500-1:2000 IF1:50-1:200
交叉反应	Human Mouse Rat
蛋白分子量	31kDa
Gene ID	958
保存	Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant Protein of human CD40
性状	Lyophilized or Liquid
Swiss Prot	P25942
克隆类型	Polyclonal Antibody
来源	Rabbit
背景资料	This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.